Antidepressants are the first line treatment for depression. Annual sales of antidepressants almost $ 50 billion, making this category of drugs and medicines, one of the leading medical prescriptions. Many pharmaceutical companies engage in direct marketing to consumers of antidepressants through television and print media. Therefore, patients have a significant impact on the patterns as health care providers when it comes to antidepressants. Are commonly prescribed antidepressants, but what, exactly? How does it work? Are they effective?